I became interested in an America campaign after reading here about the updates and changes to the game and after recently reading Empire of the Summer Moon: Quanah Parker and the Rise and Fall of the Comanches, the Most Powerful Indian Tribe in American History, by S. C. Gwynne, which describes the long but ultimately futile resistance by the Comanches to United States (and Mexican) encroachment on their lands. Of course I note in the game that Comanche land is generically described as Cherokee land, as the game uses a few Native American tribal names to substitute for the many historical tribal groups. But I am interested, among other things, in how America in the game deals with the Native Americans.
I have never played a full campaign. I've started campaigns and played the short scenarios, so I am still very much a beginner. However, I have always held this game in a certain amount of awe because of what it attempts to do. So I do think I am going to do an America campaign. And if I do, I will write at least a summary AAR. I am going through tutorials again and a couple of walkthroughs including your How To Play series before I get started.
My only concern is starting one now and then finding out I need to restart it due to the upcoming patch, though I think I need to run at least one test start to make sure I don't bungle the job too badly at the start.